Intermittent Androgen Suppression for Rising PSA Level after Radiotherapy

A new study published in the New England Journal of Medicine has shown that an intermittent approach to androgen deprivation therapy (ADT) for men with a rising PSA level after radiotherapy is equally as effective as a continuous approach.

Because many prostate cancers are dependent on androgens to grow and spread, ADT is the standard treatment for men whose cancer has not been completely eliminated by surgery or radiotherapy.  However, ADT is associated with a number of adverse side effects, including sexual dysfunction, hot flashes, fatigue, decreased bone density and muscle mass, depression and cognitive function.  Other studies have shown that intermittent ADT may reduce these side effects, resulting in improved quality of life, and may also delay hormone resistance.  The good news from this new study is that intermittent ADT does not result in a reduction in overall survival.

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